There is evidence supporting a role for Nociceptin/OrphaninFQ (N/OFQ) receptor (NOP) and its endogenous ligand N/OFQ in the modulation of neurogenic inflammation, airway tone and calibre. We hypothesised that NOP activation has beneficial effects upon asthma immunopathology and airway hyper-responsiveness. Therefore, the expression and function of N/OFQ-NOP was examined in healthy and asthmatic human airway tissues. The concept was further addressed in an animal model of allergic asthma.
Nociceptin/OrphaninFQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma
DE PALMA, Raffaele;
2016-01-01
Abstract
There is evidence supporting a role for Nociceptin/OrphaninFQ (N/OFQ) receptor (NOP) and its endogenous ligand N/OFQ in the modulation of neurogenic inflammation, airway tone and calibre. We hypothesised that NOP activation has beneficial effects upon asthma immunopathology and airway hyper-responsiveness. Therefore, the expression and function of N/OFQ-NOP was examined in healthy and asthmatic human airway tissues. The concept was further addressed in an animal model of allergic asthma.
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