Defects in the global organization of chromatin are relevant in many pathological processes, including cancer. The activation of oncogenes has been recognized as a triggering event of alterations in the dynamics of replication, transcription and DNA damage response (DDR), that may lead to increased DNA damage and the onset of genomic instability [Negrini et al, Nature Rev Mol Cell Biol (2010)]. Genome-wide sequencing methods are shedding light on the series of molecular events (e.g. replication stress) that follow oncogene activation and produce genomic damage [Macheret and Halazonetis, Nature (2018)]. However, how these events are unfolding in the context of the crowded three-dimensional nucleus and which is the role of nanoscale chromatin architecture remain to be determined yet.
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|Titolo:||Chromatin Alterations in a Model of Oncogene Activation Studied by Advanced Fluorescence Microscopy|
|Data di pubblicazione:||2019|
|Appare nelle tipologie:||04.02 - Abstract in atti di convegno|