The high-throughput generation of polymeric nanoparticles (PNPs) with tailored size and narrow size distribution is key for applications as relevant as sensing and nanomedicine. Here we show how cavitation bubbles in a microfluidic channel can induce rapid nanoprecipitation of PNPs with user-selectable control. Specifically, we used two tip-electrodes perpendicular to the flow to induce electrical breakdown of a polymer solution and a miscible non-solvent. As a result, a plasma is formed causing cavitation and rapid mixing of the fluids, yielding nanoprecipitates of polymer. We demonstrated mL/min generation of PNPs with a diameter as low as 150 nm and polydispersity below 0.15.
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Titolo: | Cavitation-Assisted Micromixing for Polymeric Nanoparticle Generation |
Autori: | |
Data di pubblicazione: | 2018 |
Rivista: | |
Handle: | http://hdl.handle.net/11567/958164 |
Appare nelle tipologie: | 04.01 - Contributo in atti di convegno |