The ever-increasing interest in nanotechnologies has led to a strong push towards the production of these products, although there is still much to understand and investigate about the characteristics and mechanisms of action of nanomaterials. Numerous indications on the toxicity of nanoparticles are emerging from the literature, linked above all to the large number of variables that influence it: dimensions, chemical composition, shape, structure and surface charge. Because of this it must be emphasized that each nanoparticle is a case in itself and as such it must be studied individually. Relevant are the possible applications in the biomedical field, which range from innovative and more effective drug delivery systems, especially in the field of oncology, to biosensors, to molecular nanotechnology. The purpose of this work is to characterize paramagnetic Fe2O3 nanoparticles to be used in drug delivery. In particular we wanted to characterize PEGylate magnetite nanoparticles to ascertain their possible toxicity on human somatic and tumor cells. Secondly, we wanted to tackle the problems due to cancer therapies to try to lengthen the periods without disease and improve the quality of life of patients. In this context we wanted to combine our nanoparticles with the chemotherapy drug Taxol Paclitaxel or Taxotere to try to obtain a reduction in the dose applied and applicable during cancer therapy and the consequent chronic degenerative pathologies related to it (eg cardiomyopathies).
|Titolo della tesi:||Nanoparticelle paramagnetiche: vantaggi, rischi e prevenzione terziaria.|
|Data di discussione:||10-apr-2019|
|Appare nelle tipologie:||Tesi di dottorato|