Tesi di dottorato

Tesi di dottorato: [2207] Home page macrotipologia

Sfoglia

Tesi di dottorato 2207

Prodotti recenti

Rational design of multi-compartmentalized µMESH implants for the treatment of brain disorders

Despite advances in targeted therapies, the survival rate for glioblastoma (GBM) patients has not improved over the past 20 years. The efficacy of GBM treatment remains constrained by non-specific distribution, tumor heterogeneity, and a highly immunosuppressive microenvironment. An innovative drug delivery system – µMESH – has recently been developed to address these challenges. This platform consists of a flexible, biodegradable, dual-compartment polymeric film, and previous results have de...

Naturally-Derived, Bioactive, Zein Microparticles for Wound Healing: Efficiency Optimization via Spray Drying

Wound healing is a delicate process comprising various phases, of which inflammation constitutes the most critical one. Some wounds fail to evolve from this state due to pre-existing pathologies or medical conditions, such as diabetes, becoming chronic and causing pain and serious consequences for the patients. Wounds are defined chronic when they fail to heal in a time span that ranges from four weeks to three months and, as an extreme consequence, can eventually lead to gangrene and patient...

Photovoltaic solar energy conversion: prediction models applied to tracking and fixed-tilt systems at European scale

The present Ph.D. thesis aims to present the development of models for diagnostic of large photovoltaic plants, the maximization of the solar radiation captured by ground-mounted bifacial plants, both fixed and single-axis tracking, and the optimization of the exploitation of the solar resource in urban-integrated systems. The first part of the work concerns the development of robust models for predicting the performance and enabling automated monitoring of large-scale photovoltaic systems,...

Macrophages and Natural Killer cells in the tumor microenvironment: towards novel immunotherapeutic approaches for neuroblastoma patients

Cancer represents one of the main causes of death in both adults and children. Immunotherapy has significantly advanced cancer treatment, improving survival rates and quality of life for a considerable proportion of patients. However, continued research is essential to enhance outcomes for those who remain resistant to current therapies. The tumor microenvironment (TME) plays a pivotal role in disease progression, driving malignant cell growth and contributing to treatment resistance. In neu...

Modification of monocyte compartments following exposure to bacterial lysates

ABSTRACT Polyvalent mechanical bacterial lysate (PMBL) has been reported to effectively prevent and treat recurrent respiratory infections, including those of viral aetiology. It confers protection and improves immune response by modulating cellular and humoral responses. Although its immunogenic capabilities have been studied in different cell types, its fine molecular mechanisms of action remain poorly elucidated. In this study, we investigated the potential immunomodulatory effects of ba...

Scopri

Accesso al fulltext

open2058
no fulltext76
embargoed70
partially open2
reserved1

Nome	Dominio	Durata	Descrizione
s_.*	plu.mx	sessione	recupero grafico citazioni sociali da plumx
A_.*	core.ac.uk	7 giorni	recupero pubblicazioni consigliate per il pannello core-recommander
GS_.*	gstatic.com	richiesta http	visualizza grafico citazioni
CC_.*	creativecommons.org	richiesta http	visualizza licenza bitstream