In the supercritical antisolvent (SAS) precipitation, the thermodynamic behavior of the system influences particles morphology. However, in the case of complex multicomponent systems, thermodynamic data are limited and there is the common tendency to neglect the solutes and consider the system as pseudo-binary (solvent−CO2). Polyvinylpyrrolidone (PVP) was precipitated using SAS from acetone-ethanol mixtures and different SAS morphologies were obtained at different operating conditions. To explain the obtained morphologies, VLEs of the ternary system acetone-ethanol−CO2 and of the quaternary system PVP-acetone-ethanol−CO2 were experimentally determined using a static synthetic method. It was evident that the presence of PVP, at different concentrations in the liquid solution, had an appreciable effect on the equilibria. Once the VLEs were determined, the morphologies of the powders precipitated by SAS were justified considering the position of the corresponding operating points with respect to the PVP-acetone-ethanol−CO2 mixture critical point.

PVP microparticles precipitation from acetone-ethanol mixtures using SAS process: Effect of phase behavior

Campardelli, Roberta;
2019-01-01

Abstract

In the supercritical antisolvent (SAS) precipitation, the thermodynamic behavior of the system influences particles morphology. However, in the case of complex multicomponent systems, thermodynamic data are limited and there is the common tendency to neglect the solutes and consider the system as pseudo-binary (solvent−CO2). Polyvinylpyrrolidone (PVP) was precipitated using SAS from acetone-ethanol mixtures and different SAS morphologies were obtained at different operating conditions. To explain the obtained morphologies, VLEs of the ternary system acetone-ethanol−CO2 and of the quaternary system PVP-acetone-ethanol−CO2 were experimentally determined using a static synthetic method. It was evident that the presence of PVP, at different concentrations in the liquid solution, had an appreciable effect on the equilibria. Once the VLEs were determined, the morphologies of the powders precipitated by SAS were justified considering the position of the corresponding operating points with respect to the PVP-acetone-ethanol−CO2 mixture critical point.
File in questo prodotto:
File Dimensione Formato  
2019 PVP microparticles.pdf

accesso chiuso

Tipologia: Documento in versione editoriale
Dimensione 4.41 MB
Formato Adobe PDF
4.41 MB Adobe PDF   Visualizza/Apri   Richiedi una copia

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/940709
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 21
  • ???jsp.display-item.citation.isi??? 21
social impact