Following the publication of our study [1] no biochemical data derived from adolescent marathon runners have been made available. However, there are two potentially relevant investigations including adult runners. Shin and colleagues demonstrated different effects depending on the running distance, i.e. marathon, 100 km and 308 km [2]. Hepatic function was more impaired after completing 308 km (low intensity, long duration) compared to marathon or 100 km, but renal dysfunction was more pronounced after marathon and especially after 100 km (higher intensity and shorter duration). Another study reported elevated creatinine levels immediately post-marathon, being equivalent to acute kidney injury (AKI) stages 1 and 2 in 82% of runners [3]. However, values returned to baseline 24 hours post-marathon as shown in adolescent runners [1]. Whether the high AKI incidence represents an age effect or is a consequence of repeated marathon running or remains clinically irrelevant has to be proved.

Research update for articles published in EJCI in 2016

Carbone, Federico;Montecucco, Fabrizio;
2018

Abstract

Following the publication of our study [1] no biochemical data derived from adolescent marathon runners have been made available. However, there are two potentially relevant investigations including adult runners. Shin and colleagues demonstrated different effects depending on the running distance, i.e. marathon, 100 km and 308 km [2]. Hepatic function was more impaired after completing 308 km (low intensity, long duration) compared to marathon or 100 km, but renal dysfunction was more pronounced after marathon and especially after 100 km (higher intensity and shorter duration). Another study reported elevated creatinine levels immediately post-marathon, being equivalent to acute kidney injury (AKI) stages 1 and 2 in 82% of runners [3]. However, values returned to baseline 24 hours post-marathon as shown in adolescent runners [1]. Whether the high AKI incidence represents an age effect or is a consequence of repeated marathon running or remains clinically irrelevant has to be proved.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11567/927825
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