There is an unmet need for engineering small vascular graft that can be anastomosed without inducing thrombosis. The objective of this work is to fabricate tubular graft with 2 mm of diameter with biomimetic mechanical and biological properties. Poly(ε-caprolactone) and poly(glycerol sebacate) blends with different concentrations and ratios are used to fabricate fibrous grafts using electrospinning process. Porous and degradable scaffolds with enhanced mechanical properties and comparable suture retention to the native human artery are fabricated. Scaffold–blood interaction revealed good anticoagulation properties. The fabricated constructs can serve as biocompatible and hemocompatible vascular graft with enhanced mechanical properties.

Tailored electrospun small-diameter graft for vascular prosthesis

FERRARI, PIER FRANCESCO;ALIAKBARIAN, BAHAR;LAGAZZO, ALBERTO;PALOMBO, DOMENICO;PEREGO, PATRIZIA
2017

Abstract

There is an unmet need for engineering small vascular graft that can be anastomosed without inducing thrombosis. The objective of this work is to fabricate tubular graft with 2 mm of diameter with biomimetic mechanical and biological properties. Poly(ε-caprolactone) and poly(glycerol sebacate) blends with different concentrations and ratios are used to fabricate fibrous grafts using electrospinning process. Porous and degradable scaffolds with enhanced mechanical properties and comparable suture retention to the native human artery are fabricated. Scaffold–blood interaction revealed good anticoagulation properties. The fabricated constructs can serve as biocompatible and hemocompatible vascular graft with enhanced mechanical properties.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/881123
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