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EnglishObjective: To evaluate the efficacy as antihypercholesterolemic agent of berberine in patients with low cardiovascular risk. Research design and methods: 144 Caucasian subjects were enrolled. After a 6-month run-in period following diet and practicing physical activity, patients were randomized to take placebo or berberine 500 mg twice a day, for 3 months, in a double-blind, placebo-controlled design. Berberine and placebo were then interrupted for 2 months (washout period), and all patients continued with only diet and physical activity. At the end of the washout period, patients restarted berberine or placebo twice a day for further 3 months. Anthropometric and metabolic parameters were assessed during the run-in period, at randomization, before and after the washout period. Results: A decrease of body weight and BMI was observed after the run-in period. Berberine reduced total cholesterol, triglycerides and LDL cholesterol and increased HDL cholesterol after 3 months from randomization and compared with placebo. After the washout period, lipid profile worsened; afterward, when berberine was reintroduced, lipid profile improved again both compared with the washout period, and with placebo. Conclusions: Berberine is effective and safe to mildly improve lipid profile in subjects with low risk for cardiovascular disease. © 2013 Informa UK, Ltd.
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| Titolo: | Effects of berberine on lipid profile in subjects with low cardiovascular risk |
| Autori: | |
| Data di pubblicazione: | 2013 |
| Rivista: | |
| Handle: | http://hdl.handle.net/11567/858835 |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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