Apathy is the most common initial symptom of frontotemporal dementia (FTD) and has been linked to frontal-subcortical dopaminergic system dysfunction. No pharmacological therapy has been approved for the treatment of apathy, but, on the basis of its physiopathological mechanism, we suspected that increasing prefrontal dopaminergic innervation could improve this disabling symptom.
Agomelatine Improves Apathy in Frontotemporal Dementia
MATTEI, CHIARA;SASSOS, DAVIDE;MASSUCCO, DAVIDE;SCIALO', CARLO;NOBILI, FLAVIO MARIANO;SERRATI, CARLO;AMORE, MARIO;COCITO, LEONARDO;PARDINI, MATTEO
2016
Abstract
Apathy is the most common initial symptom of frontotemporal dementia (FTD) and has been linked to frontal-subcortical dopaminergic system dysfunction. No pharmacological therapy has been approved for the treatment of apathy, but, on the basis of its physiopathological mechanism, we suspected that increasing prefrontal dopaminergic innervation could improve this disabling symptom.
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