To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite ACT-132577, and bosentan on myofibroblast activation and extracellular matrix production induced by ET-1 in cultured systemic sclerosis (SSc) and control skin fibroblasts.
Effects of macitentan and its active metabolite on cultured human systemic sclerosis and control skin fibroblasts
CUTOLO, MAURIZIO;MONTAGNA, PAOLA;BRIZZOLARA, RENATA;ALESSANDRI, ELISA;VILLAGGIO, BARBARA;SULLI, ALBERTO;Tavilla, Pietro Paolo;PIZZORNI, CARMEN;SOLDANO, STEFANO
2015-01-01
Abstract
To investigate the effects of the endothelin 1 (ET-1) receptor antagonists (ETRA) macitentan, its active metabolite ACT-132577, and bosentan on myofibroblast activation and extracellular matrix production induced by ET-1 in cultured systemic sclerosis (SSc) and control skin fibroblasts.
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JRheumatol2015;42;456-63. Effects of Macicentan.pdf
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