A nanoarray or microarray of antibodies comprising a planar surface having an ultraflat surface is described, which is characterized in that it comprises a planar substrate functionalized with a first monolayer of linking molecules, preferably APTES molecules, and a second monolayer of small peptides of the general formula (I) capable of binding the Fc region of antibodies. The nanoarray or microarray of the invention comprises a plurality of capture antibodies immobilized on the planar support, preferably in the form of a matrix of spots, and is suitable to be used for detecting antigens in a biological sample by AFM imaging. Z-HN-R1-R2-R3-R4-R5-R6-NH-X-CO-G-CO
A PLANAR SUPPORT HAVING AN ULTRAFLAT SURFACE AND A DEVICE FOR DETECTING ANTIGENS COMPRISING SAID PLANAR SUPPORT
FERRERA FRANCESCA;IERARDI, VINCENZO;FILACI, GILBERTO;MILLO ENRICO;DAMONTE, GIANLUCA;VALBUSA, UGO
2014-01-01
Abstract
A nanoarray or microarray of antibodies comprising a planar surface having an ultraflat surface is described, which is characterized in that it comprises a planar substrate functionalized with a first monolayer of linking molecules, preferably APTES molecules, and a second monolayer of small peptides of the general formula (I) capable of binding the Fc region of antibodies. The nanoarray or microarray of the invention comprises a plurality of capture antibodies immobilized on the planar support, preferably in the form of a matrix of spots, and is suitable to be used for detecting antigens in a biological sample by AFM imaging. Z-HN-R1-R2-R3-R4-R5-R6-NH-X-CO-G-CO
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