The oxidant/antioxidant status of patients could influence tumor growth and proliferation and subsequently overall survival. Lipid hydroperoxides (LOOHs) accumulate, not in young and proliferating cells, but in aging cells, suggesting that this intracellular increasing should restore the capability of tumour cells to age and die. Potential antitumoral effects of LOOHs, were verified in vitro on a human bladder (5637), and normal endothelial (HECV) cell lines by analysis of proliferation rate, oxidative markers and several molecules involved into neoplastic progression. LOOH exposure may exhibit different effects on cancer and normal cell proliferation, and the mechanism on the growth inhibitory activity of LOOHs seems to be associated to the reduction of APRIL and other proangiogenic factors.
ANTI-TUMOR EFFECTS OF LIPOPEROXIDES IN VITRO
SCANAROTTI, CHIARA;PRONZATO, MARIA ADELAIDE;BASSI, ANNA MARIA
2011-01-01
Abstract
The oxidant/antioxidant status of patients could influence tumor growth and proliferation and subsequently overall survival. Lipid hydroperoxides (LOOHs) accumulate, not in young and proliferating cells, but in aging cells, suggesting that this intracellular increasing should restore the capability of tumour cells to age and die. Potential antitumoral effects of LOOHs, were verified in vitro on a human bladder (5637), and normal endothelial (HECV) cell lines by analysis of proliferation rate, oxidative markers and several molecules involved into neoplastic progression. LOOH exposure may exhibit different effects on cancer and normal cell proliferation, and the mechanism on the growth inhibitory activity of LOOHs seems to be associated to the reduction of APRIL and other proangiogenic factors.
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