Oxidation antitumor therapy is developed by delivering excess oxidative stress into tumor cells or targetedly disrupting the antioxidant systems. In present study, several markers related to oxidative stress, proliferation and angiogenesis were evaluated in human DLD-1 colon carcinoma, and HECV normal endothelial cells, during exposure to 0.1-1% Lipopeorxides (LOOH). To mimic the environment surrounding neoplasm mass, HECV are also exposed to conditioned medium derived by DLD-1 subjected or not to LOOHs. Observed LOOH cytostatic effects on tumor cells and angiogenesis inhibition, may be related to an imbalance of redox status and an increase of oxidative stress. Thus LOOHs may be promising in co-adjuvant tumor therapy
Effects of in vitro exposure to lipoperoxides in human colon adenocarcinoma and normal endotheliocyte cells are dependent by ROS-modulation of angiogenesis and proliferation markers.
SCANAROTTI, CHIARA;PENCO, SUSANNA;PRONZATO, MARIA ADELAIDE;BASSI, ANNA MARIA
2012
Abstract
Oxidation antitumor therapy is developed by delivering excess oxidative stress into tumor cells or targetedly disrupting the antioxidant systems. In present study, several markers related to oxidative stress, proliferation and angiogenesis were evaluated in human DLD-1 colon carcinoma, and HECV normal endothelial cells, during exposure to 0.1-1% Lipopeorxides (LOOH). To mimic the environment surrounding neoplasm mass, HECV are also exposed to conditioned medium derived by DLD-1 subjected or not to LOOHs. Observed LOOH cytostatic effects on tumor cells and angiogenesis inhibition, may be related to an imbalance of redox status and an increase of oxidative stress. Thus LOOHs may be promising in co-adjuvant tumor therapy
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