Despite many therapeutic advances leading to increasingly effective drug treatments, thrombotic events (such as ischaemic stroke, pulmonary embolism, deep venous thrombosis and acute myocardial infarction) still represent a major worldwide cause of morbidity and mortality. Remarkable effort has been made to identify new drug targets. There is growing evidence indicating that the recently described counter-regulator axis of the renin-angiotensin system (RAS), composed of Angiotensin-Converting Enzyme 2 (ACE2), Angiotensin-(1-7) and the Mas receptor, has protective effects against thrombosis. In addition, it could be considered as a promising target for treating or preventing this disease. In this narrative review, we focused on the recent findings of the role of the ACE2/Angiotensin-(1-7)/Mas axis on the haemostatic process and its therapeutic potential.
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Titolo: | The Angiotensin-Converting Enzyme 2/Angiotensin-(1-7)/Mas receptor axis: a potential target for treating thrombotic diseases. |
Autori: | |
Data di pubblicazione: | 2012 |
Rivista: | |
Handle: | http://hdl.handle.net/11567/450520 |
Appare nelle tipologie: | 01.01 - Articolo su rivista |