The trimethylsilyl trifluoromethanesulphonate catalyzed condensation of silyl ketene acetals with imines afforded β-amino esters with prevalent anti relative diastereoselectivity (up to 100%). Some anti β-amino esters have been then cyclized to trans β-lactams.
Diastereoselection in Trimethylsilyl Trifluoromethanesulphonate Catalyzed Reaction of Silyl Ketene Acetals with Imines
GUANTI, GIUSEPPE;NARISANO, ENRICA;BANFI, LUCA
1987-01-01
Abstract
The trimethylsilyl trifluoromethanesulphonate catalyzed condensation of silyl ketene acetals with imines afforded β-amino esters with prevalent anti relative diastereoselectivity (up to 100%). Some anti β-amino esters have been then cyclized to trans β-lactams.
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