Enantiomerically pure t-Butyl 2-amino-2,5-dideoxy---pentanoate 4c is synthesized via the highly diastereoselective MgBr2 mediated addition of dibenzylamino acetate silylketene acetal 2 to O-benzyl lactic aldehyde 3. The synthesis of γ-lactone 5c, a known intermediate in the synthesis of L-daunosamine and L-vancosamine, is also described.

Stereoselective Synthesis of t -Butyl 2-Amino-2,5-dideoxy-L-lyxo-pentanoate: Formal Synthesis of L-Daunosamine

BANFI, LUCA;
1987

Abstract

Enantiomerically pure t-Butyl 2-amino-2,5-dideoxy---pentanoate 4c is synthesized via the highly diastereoselective MgBr2 mediated addition of dibenzylamino acetate silylketene acetal 2 to O-benzyl lactic aldehyde 3. The synthesis of γ-lactone 5c, a known intermediate in the synthesis of L-daunosamine and L-vancosamine, is also described.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/391235
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