The aminothiazolopyrimidinones I (R = Me, Et; R1 = Me, Et, CH2Ph, Ph; NRR1 = pyrrolidino) were obtained together with the isomers II by treating RR1NCOCH2CO2Et with POCl3, followed by condensation of the imino chloride with 2-aminothiazole. I (R = Me, Et; R1 = Ph) had some analgesic activity. I were devoid of cerebral nervous system activity.
[Derivatives of 1,2-condensed pyrimidines. II. Synthesis and pharmacological study of N,N-disubstituted 5-amino-7H-thiazol [3,2-a]pyrimdine-7-ones].
DI BRACCIO, MARIO;MAZZEI, MAURO;BALBI, ALESSANDRO;
1986-01-01
Abstract
The aminothiazolopyrimidinones I (R = Me, Et; R1 = Me, Et, CH2Ph, Ph; NRR1 = pyrrolidino) were obtained together with the isomers II by treating RR1NCOCH2CO2Et with POCl3, followed by condensation of the imino chloride with 2-aminothiazole. I (R = Me, Et; R1 = Ph) had some analgesic activity. I were devoid of cerebral nervous system activity.
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