The preparation of 3-alkyl-4-(chloromethyl)-1-RSO2-1H-pyrrol-2(5H)-ones was efficiently accomplished through a [1,2]-elimination of -lactams derived from the copper (I)-catalysed ATRC of 2,2-dichloro-N-(2-chloroallyl)-N-RSO2-amides. The two reactions can be integrated into a sequential one-pot process.
Synthesis of 3-alkyl-4-(chloromethyl)-3-alkyl-1-RSO2-1H-pyrrol-2(5H)-ones, using a sequential ATRC/[1,2]-elimination, from 2,2-dichloro-N-(2-chloroallyl)-N-RSO2-amides
PETRILLO, GIOVANNI;
2011-01-01
Abstract
The preparation of 3-alkyl-4-(chloromethyl)-1-RSO2-1H-pyrrol-2(5H)-ones was efficiently accomplished through a [1,2]-elimination of -lactams derived from the copper (I)-catalysed ATRC of 2,2-dichloro-N-(2-chloroallyl)-N-RSO2-amides. The two reactions can be integrated into a sequential one-pot process.File in questo prodotto:
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