In the subcommissuralorgan of male rats, a circumventricular organ situated inside the blood-brain barrier,specificreceptors for angiotensinII were demonstrated by binding studies on homogenated membranes and by autoradiography carried out on frozen sections using 125I-angiotensinII. The receptor sites were localized in the subnuclear region of cells of the subcommissuralorgan. A single class of binding sites was found whose capacity was modulated by changes in the sodium plasma concentration which led to variations in plasma volume.
Angiotensin II specific receptors in subcommissural organ.
GHIANI, PIETRO;UVA, BIANCA MARIA;VALLARINO, MAURO;MANDICH, ALBERTA;MASINI, MARIA ANGELA
1988-01-01
Abstract
In the subcommissuralorgan of male rats, a circumventricular organ situated inside the blood-brain barrier,specificreceptors for angiotensinII were demonstrated by binding studies on homogenated membranes and by autoradiography carried out on frozen sections using 125I-angiotensinII. The receptor sites were localized in the subnuclear region of cells of the subcommissuralorgan. A single class of binding sites was found whose capacity was modulated by changes in the sodium plasma concentration which led to variations in plasma volume.
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