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EnglishWe describe the histological examination of 18 aborted fetuses that had increased nuchal translucency {(NT)} between 11(+0) and 13(+6) weeks' gestation. The aim of this study was to assess the corresponding {NT} anatomic features by immunohistochemical {(IHC)} investigation. A morphological study was performed using lymphatic and blood endothelial specific markers, as well as smooth muscle actin {(SMA).} We found that all 18 cases were D2-40 positive, {CD31} positive, and {CD34} negative, suggesting the presence of nuchal lymph vessel ectasia. We found that 12/18 cases were SMA staining positive and 6/18 cases were SMA negative, suggesting that 6/18 cases had nuchal cystic lymphangiectasia, whereas 12/18 had cystic hygromas. The present data seem to confirm the reasonable hypothesis that lymphangiogenesis plays a relevant role in nuchal edema, increased NT, and that increased NT is the result of a lymphatic malformation or a delayed development of the lymphatic system.
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| Titolo: | Nuchal translucency and lymphatic system maldevelopment | |
| Autori: | ||
| Data di pubblicazione: | 2009 | |
| Rivista: | ||
| Abstract: | We describe the histological examination of 18 aborted fetuses that had increased nuchal translucency {(NT)} between 11(+0) and 13(+6) weeks' gestation. The aim of this study was to assess the corresponding {NT} anatomic features by immunohistochemical {(IHC)} investigation. A morphological study was performed using lymphatic and blood endothelial specific markers, as well as smooth muscle actin {(SMA).} We found that all 18 cases were D2-40 positive, {CD31} positive, and {CD34} negative, suggesting the presence of nuchal lymph vessel ectasia. We found that 12/18 cases were SMA staining positive and 6/18 cases were SMA negative, suggesting that 6/18 cases had nuchal cystic lymphangiectasia, whereas 12/18 had cystic hygromas. The present data seem to confirm the reasonable hypothesis that lymphangiogenesis plays a relevant role in nuchal edema, increased NT, and that increased NT is the result of a lymphatic malformation or a delayed development of the lymphatic system. | |
| Handle: | http://hdl.handle.net/11567/308889 | |
| Appare nelle tipologie: | 01.01 - Articolo su rivista |
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