A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protectedcystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bondformation in this kind of oligomers, which are traditionally obtained by liquid phase coupling via oxidation of the two terminalcysteines.
Optimised solid phase synthesis of a cystine-linked peptide-PNA chimera
MILLO, ENRICO;SCARFI', SONIA;SCAPOLLA, CARLO;BENATTI, UMBERTO;DAMONTE, GIANLUCA
2002-01-01
Abstract
A solid phase synthesis method for a cystine-linked peptide-PNA chimera starting from different modified protectedcystine monomers was developed. This strategy dramatically improved the final yield and the specificity of disulphide bondformation in this kind of oligomers, which are traditionally obtained by liquid phase coupling via oxidation of the two terminalcysteines.
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