The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones also alpha,beta-unsaturated and oxiranes, and cleavage of the produced dithioketal-protected alpha- or beta-hydroxyketones with various reagents have been studied.
Polymer-supported Synthesis of α- and ß-Hydroxyketones through the Formation of 1,3-Dithiane Intermediates
BERTINI, VINCENZO;LUCCHESINI, FRANCESCO;POCCI, MARCO;ALFEI, SILVANA;
2008-01-01
Abstract
The synthesis of polymer-supported 2-monosubstituted 1,3-dithianes from soluble copolymers bearing 1,3-propanedithiol groups, their lithiation, reactions with electrophiles such as aldehydes, ketones also alpha,beta-unsaturated and oxiranes, and cleavage of the produced dithioketal-protected alpha- or beta-hydroxyketones with various reagents have been studied.
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