A substantial body of evidence indicates that protein kinase C (PKC) is involved in the alpha-secretory processing of the amyloid precursor protein (APP), an event that reduces the formation of the pathogenic amyloid-beta peptide. Recently, we have shown that trafficking and processing of APP are both impaired by knockdown of myosin II-B, one of the major neuronal motor proteins. Here, we provide evidence that the alpha-secretory processing of APP is mediated by PKC-dependent phosphorylation of myosin II-B. This signaling pathway provides an important link between APP and the neuronal cytoskeleton and might be crucial for the understanding of the biological and pathological roles of APP.

Protein kinase C-dependent {alpha}-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B

ARGELLATI, FRANCESCA;DOMENICOTTI, CINZIA MARIA;PASSALACQUA, MARIO;MELLONI, EDON;MARINARI, UMBERTO;PRONZATO, MARIA ADELAIDE;RICCIARELLI, ROBERTA
2009-01-01

Abstract

A substantial body of evidence indicates that protein kinase C (PKC) is involved in the alpha-secretory processing of the amyloid precursor protein (APP), an event that reduces the formation of the pathogenic amyloid-beta peptide. Recently, we have shown that trafficking and processing of APP are both impaired by knockdown of myosin II-B, one of the major neuronal motor proteins. Here, we provide evidence that the alpha-secretory processing of APP is mediated by PKC-dependent phosphorylation of myosin II-B. This signaling pathway provides an important link between APP and the neuronal cytoskeleton and might be crucial for the understanding of the biological and pathological roles of APP.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/248418
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