Surface NK receptors and their ligands on tumors cells

Moretta, Alessandro; Bottino, Cristina; Pende, D; Castriconi, Roberta; Mingari, MARIA CRISTINA; Moretta, Lorenzo

doi:10.1016/j.smim.2006.03.002

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The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity. Thus, under pathological conditions, NK cells may express insufficient amounts of triggering receptors and target cells may or may not express ligands for such receptors. Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis.

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Titolo:	Surface NK receptors and their ligands on tumors cells
Autori:	MORETTA, ALESSANDRO BOTTINO, CRISTINA Pende D CASTRICONI, ROBERTA MINGARI, MARIA CRISTINA MORETTA, LORENZO mostra contributor esterni nascondi contributor esterni
Data di pubblicazione:	2006
Rivista:	SEMINARS IN IMMUNOLOGY
Abstract:	The identification of MHC-class I-specific inhibitory receptors in humans and mice provided a first explanation of why NK cells can kill target cells that have lost or underexpress MHC-class I molecules but spare normal cells. However, the molecular basis of NK-mediated recognition and tumor cell killing revealed a higher degree of complexity. Thus, under pathological conditions, NK cells may express insufficient amounts of triggering receptors and target cells may or may not express ligands for such receptors. Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis.
Handle:	http://hdl.handle.net/11567/248250
Appare nelle tipologie:	01.01 - Articolo su rivista

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