The potential anxiolytic and anti-depressive activity of CMPI was Studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMPI on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMPI, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina
First Evidence for an Anxiolytic Effect of a Diterpenoid from Salvia cinnabarina
BISIO, ANGELA;ROMUSSI, GIOVANNI;
2009-01-01
Abstract
The potential anxiolytic and anti-depressive activity of CMPI was Studied in the elevated plus-maze test and in the forced swimming test. Furthermore, CMP1 sedative activity was evaluated in pentobarbital treated animals; the effect of CMPI on spontaneous motor activity (total locomotion) was also evaluated. Our data show that CMPI, at doses that did not affect locomotion, was able to induce anxiolytic and sedative, but not anti-depressive effects. In conclusion, our results represent first evidence for an anxiolytic activity of this diterpenoid from Salvia cinnabarina
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