Various dihydrobenzo[f ][1,4]oxazepin-5-ones have been convergently prepared in 2–3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 steps); in the second one an intermolecular Mitsunobu reaction was followed by a deprotection step and then by an intramolecular Ugi reaction. Also a “convertible” isocyanide was used.

Multicomponent synthesis of dihydrobenzoxazepinones by coupling Ugi and Mitsunobu reactions

BANFI, LUCA;BASSO, ANDREA;GUANTI, GIUSEPPE;RIVA, RENATA
2006

Abstract

Various dihydrobenzo[f ][1,4]oxazepin-5-ones have been convergently prepared in 2–3 steps by coupling Ugi and Mitsunobu reactions. Two alternative methodologies were used: in the first one the Ugi condensation was followed by a Mitsunobu cyclization (2 steps); in the second one an intermolecular Mitsunobu reaction was followed by a deprotection step and then by an intramolecular Ugi reaction. Also a “convertible” isocyanide was used.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/247551
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