Single oral doses of norfloxacin (4, 2, 1, 0.5 mmole/kg) administered to pregnant rats significantly increase the frequency of micronucleated polychromatic erythrocytes both in fetal liver and in maternal bone marrow. Therefore norfloxacin in this work has been found to be a genotoxic agent.
Micronucleus formation in fetal maternal rat erythroblasts after norfloxacin transplacental administration.
MAURA, ANNA LISA;PINO, ALBIANA;GARDELLA, ANNA;FALUGI, CARLA
1994-01-01
Abstract
Single oral doses of norfloxacin (4, 2, 1, 0.5 mmole/kg) administered to pregnant rats significantly increase the frequency of micronucleated polychromatic erythrocytes both in fetal liver and in maternal bone marrow. Therefore norfloxacin in this work has been found to be a genotoxic agent.
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