Salvia miniata Fernald [1], is a Mexican species whose aerial part exudate showed herbicide activity against common weeds (Papaver rhoeas L. and Avena sativa L.) in a preliminary test. Our research is devoted to the identification of growth inhibitors with diterpene and triterpene skeletons, whose herbicidal activity has been described in literature [2], contained in the surface exudates that are generally known as natural pesticides [3]. The surface exudate, obtained by rinsing the plant material with CH2Cl2, and subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to reversed-phase semi-preparative HPLC, yielded two new clerodane diterpenoids (1, 2) identified by IR and NMR analysis, including TOCSY, COSY, HSQC and HMBC experiments.References 1. Epling, C. (1940) A Revision of Salvia, subgenus Calosphace. In: Repertorium Specierum Novarum Regni Vegetabilis. Vol.110. Fedde F., University of California Press: Berkley, California. 2. Vyvyan, J.R. (2002) Tetrahedron 58, 1631-1646. 3. Dayan, F.E., Duke, S.O. (2003). Pesticide Outlook, 8, 175-178.
New Diterpenoids from Salvia miniata Fernald (Lamiaceae).
BISIO, ANGELA;ROMUSSI, GIOVANNI;RUSSO, ELEONORA;CAFAGGI, SERGIO;
2008-01-01
Abstract
Salvia miniata Fernald [1], is a Mexican species whose aerial part exudate showed herbicide activity against common weeds (Papaver rhoeas L. and Avena sativa L.) in a preliminary test. Our research is devoted to the identification of growth inhibitors with diterpene and triterpene skeletons, whose herbicidal activity has been described in literature [2], contained in the surface exudates that are generally known as natural pesticides [3]. The surface exudate, obtained by rinsing the plant material with CH2Cl2, and subjected to repeated column chromatography on Sephadex LH-20 and silica gel and to reversed-phase semi-preparative HPLC, yielded two new clerodane diterpenoids (1, 2) identified by IR and NMR analysis, including TOCSY, COSY, HSQC and HMBC experiments.References 1. Epling, C. (1940) A Revision of Salvia, subgenus Calosphace. In: Repertorium Specierum Novarum Regni Vegetabilis. Vol.110. Fedde F., University of California Press: Berkley, California. 2. Vyvyan, J.R. (2002) Tetrahedron 58, 1631-1646. 3. Dayan, F.E., Duke, S.O. (2003). Pesticide Outlook, 8, 175-178.
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