The presence of chemical cross-reactivity betwen drugs may be an underestimated factor, responsible for decreased bio-availability of a drug active component(s); the absence of chemical cross-reactivity between drugs is undoubtedly the prerequisite for their simultaneous co-administration. Here, by means of thin layer chromatography, we show that cefixime, a third generation oral cephalosporin, does not display chemical reactivity versus a series of non-steroidal antiinflammatory agents. The four compounds tested can therefore be safely soluted together with the cephalosporin.

Assessing the chemical cross-reaction from cefixime and some non-steroidal anti-inflammatory agents in a soluble formulation

SPALLAROSSA, ANDREA
2001

Abstract

The presence of chemical cross-reactivity betwen drugs may be an underestimated factor, responsible for decreased bio-availability of a drug active component(s); the absence of chemical cross-reactivity between drugs is undoubtedly the prerequisite for their simultaneous co-administration. Here, by means of thin layer chromatography, we show that cefixime, a third generation oral cephalosporin, does not display chemical reactivity versus a series of non-steroidal antiinflammatory agents. The four compounds tested can therefore be safely soluted together with the cephalosporin.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11567/214073
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