The November ESHRE Journal Club discussion focused on a study by Wu et al. (2023) that addressed the concept of chemoprotection of ovary during chemotherapy with taxane-platinum (TP) regime. The chemoprotection was induced with CHEK1/2 inhibitors using a model where a human ovary and tumour were xenotransplanted to a mouse receiving TP chemotherapy. The results showed that the tumour was reduced and the primordial follicles were preserved. Further research into this direction concerns experimental and clinical considerations. Tap63alpha, tumour protein p63 alpha; CHEK 1/2, checkpoint 1/2.
Chemoprotection of the ovary: a leading role or a complementary strategy in fertility preservation?
Massarotti C;Lambertini M;
2024-01-01
Abstract
The November ESHRE Journal Club discussion focused on a study by Wu et al. (2023) that addressed the concept of chemoprotection of ovary during chemotherapy with taxane-platinum (TP) regime. The chemoprotection was induced with CHEK1/2 inhibitors using a model where a human ovary and tumour were xenotransplanted to a mouse receiving TP chemotherapy. The results showed that the tumour was reduced and the primordial follicles were preserved. Further research into this direction concerns experimental and clinical considerations. Tap63alpha, tumour protein p63 alpha; CHEK 1/2, checkpoint 1/2.
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