Bone remodeling requires a delicate balance between bone-forming osteoblasts and bone-resorping osteoclasts. However, in pathological conditions, bone remodeling is often deregulated and the uncoupling of osteoclasts and osteoblasts functions may alter the extent of bone loss. Although in Chronic Lymphocytic Leukemia (CLL) patients macroscopic skeletal involvement appears to be more rare than in other lymphoproliferative diseases, recent studies have however highlighted that the active cross-talk between leukemic B cells and bone tissue components may lead to alteration of bone homeostasis already at early stages of the disease, becoming further more evident in the advanced stages. Since the pathogenesis of bone involvement in CLL is not completely understood this manuscript provides an overview of clinical and biological data related to bone erosion in this disease.
Unraveling the bone-tissue microenvironment in Chronic Lymphocytic Leukemia
Paolo Giannoni;Cecilia Marini;Giovanna Cutrona;GianMario Sambuceti;Franco Fais;
2023-01-01
Abstract
Bone remodeling requires a delicate balance between bone-forming osteoblasts and bone-resorping osteoclasts. However, in pathological conditions, bone remodeling is often deregulated and the uncoupling of osteoclasts and osteoblasts functions may alter the extent of bone loss. Although in Chronic Lymphocytic Leukemia (CLL) patients macroscopic skeletal involvement appears to be more rare than in other lymphoproliferative diseases, recent studies have however highlighted that the active cross-talk between leukemic B cells and bone tissue components may lead to alteration of bone homeostasis already at early stages of the disease, becoming further more evident in the advanced stages. Since the pathogenesis of bone involvement in CLL is not completely understood this manuscript provides an overview of clinical and biological data related to bone erosion in this disease.
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
