The 3-phenyl pyrazoles 1 and the anilino pyrazoles 2 were identified as effective antimalarial agents. Through a molecular hybridization strategy, a library pyrazoles 3 was designed, synthesized and tested for antiplasmodial properties. 5-Anilino pyrazoles 3a-p were screened for their antimalarial properties using Chloroquine (CQ) as reference drug. CQ-sensitive D10 and the CQ-resistant W2 P. falciparum strains were considered.
Regioselective synthesis and structural characterization of novel tri- and tetra- substituted anilino pyrazoles endowed with antimalarial activity
Matteo Lusardi;Erika Iervasi;Andrea Spallarossa
2023-01-01
Abstract
The 3-phenyl pyrazoles 1 and the anilino pyrazoles 2 were identified as effective antimalarial agents. Through a molecular hybridization strategy, a library pyrazoles 3 was designed, synthesized and tested for antiplasmodial properties. 5-Anilino pyrazoles 3a-p were screened for their antimalarial properties using Chloroquine (CQ) as reference drug. CQ-sensitive D10 and the CQ-resistant W2 P. falciparum strains were considered.
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