An optimum mobile-phase composition is proposed for resolution of the impurities in dithranol and compounds related to dithranol by isocratic reversed-phase HPLC in a single run. A combination of Snyder's solvent selectivity triangle concept with mixture design was used to achieve this goal. The quantification of the five substances involved was tested and the ruggedness of the method verified for small changes in the mobile phase composition.
Optimization of the isocratic separation of dithranol and related compounds by reversed-phase liquid chromatography
Leardi R.;
1997-01-01
Abstract
An optimum mobile-phase composition is proposed for resolution of the impurities in dithranol and compounds related to dithranol by isocratic reversed-phase HPLC in a single run. A combination of Snyder's solvent selectivity triangle concept with mixture design was used to achieve this goal. The quantification of the five substances involved was tested and the ruggedness of the method verified for small changes in the mobile phase composition.
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