Three-dimensional tumor models are becoming extensively employed in cancer research due to their accessibility and close representation of physiological tumor conditions. Hence, novel oncological diagnostic, therapeutic and combined theranostic platforms, including nanomaterial-based systems, are increasingly evaluated at preclinical stage by means of such models. Here, we provide an overview of the functional features and methods of preparation of some of the most interesting 3D tumor models, with a special attention to the classical and widely utilized multicellular tumor spheroids. Their applications in nanomaterial biosafety and efficacy assessment are highlighted, along with the suitable evaluating techniques. Overall, this review comprehensively illustrates the significant role of 3D tumor models towards the translation of nanomaterials to clinics. Their inclusion in biomedical and preclinical research workflow may address the issues related to both the conventional two-dimensional cell cultures and animal models, ultimately promoting breakthroughs in cancer nanotheranostics research.

Three-Dimensional Tumor Models: Promoting Breakthroughs in Nanotheranostics Translational Research

Voliani V
2020-01-01

Abstract

Three-dimensional tumor models are becoming extensively employed in cancer research due to their accessibility and close representation of physiological tumor conditions. Hence, novel oncological diagnostic, therapeutic and combined theranostic platforms, including nanomaterial-based systems, are increasingly evaluated at preclinical stage by means of such models. Here, we provide an overview of the functional features and methods of preparation of some of the most interesting 3D tumor models, with a special attention to the classical and widely utilized multicellular tumor spheroids. Their applications in nanomaterial biosafety and efficacy assessment are highlighted, along with the suitable evaluating techniques. Overall, this review comprehensively illustrates the significant role of 3D tumor models towards the translation of nanomaterials to clinics. Their inclusion in biomedical and preclinical research workflow may address the issues related to both the conventional two-dimensional cell cultures and animal models, ultimately promoting breakthroughs in cancer nanotheranostics research.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/1102047
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