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EnglishPurpose: The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with TAO and their relationship with clinical features and disease activity using SD-OCT and Angio-OCT technology. Methods: Eighteen patients and control subjects underwent a complete eye examination, OCT and angio - OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2 and L3) below the choriocapillary. Results: The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared to 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E - 07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared to healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E - 07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168). Conclusions: Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared to healthy subjects.
| Titolo della tesi: | Evaluation of retinal, choroidal and peripapillary vascular flow in patients with Thyroid Associated Ophthalmopathy (TAO) using Optical Coherence Tomography Angiography (OCT-A) | |
| Autori: | ||
| Data di discussione: | 8-apr-2022 | |
| Abstract: | Purpose: The aim of this study was to evaluate changes in choroidal thickness and in choroidal vascular blood flow in patients with TAO and their relationship with clinical features and disease activity using SD-OCT and Angio-OCT technology.
Methods: Eighteen patients and control subjects underwent a complete eye examination, OCT and angio - OCT. We also obtained angiographic scans at 3 different consecutive levels (L1, L2 and L3) below the choriocapillary.
Results: The subfoveal choroid was significantly thicker in TAO patients than the control eyes (285.6275 ± 32.5 μm compared to 135.89 ± 19.8 μm, respectively, p = 0.0089). The correlation analysis in the TAO group showed a significant correlation between the choroidal thickness and EUGOGO clinical score (r = 0.84, p = 8.44032E - 07). Vascular flow of choriocapillary was markedly reduced in subjects with TAO compared to healthy subjects (49.78 ± 4.5 vs. 53.36 ± 1.07; p = 2.5105E - 07) and vascular flow of the deeper layer L3 resulted higher in subjects with TAO than in healthy subjects (46.9 ± 20.23 and 41.475 ± 3.06; p = 0.01168).
Conclusions: Subfoveal choroidal thickness and choroidal blood flow were significantly different in patients with TAO compared to healthy subjects. Purpose The aim of this study is to evaluate the changes in macular blood flow index (BFI) in patients with moderate to severe thyroid-associated orbitopathy (TAO) before and after pulse therapy and their relationship with clinical features and disease activity using angio-OCT technology. Methods We analyzed twenty-four eyes. Every patient underwent a complete eye examination and angio-OCT analysis (OCT Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) before (T0) and two months (T2) after pulse therapy. We analyzed macular vascular blood flow in four angiographic levels: superficial plexus (SP), deep plexus (DP), external retina (ER), and choriocapillaris (CC). We used the clinical activity score (CAS) score to define TAO as moderate or severe. Results Macular BFI significantly increased at T2 in the DP, ER, and CC (p < 0.01). CAS score (5.8 ± 0.8 vs. 3.9 ± 0.9, p < 0.01) and Hertel exophthalmometry values (22.6 ± 2.3 mm vs. 21.2 ± 2,5 mm, p < 0.01) improved for all patients at T2 compared T0. Mean IOP increased from 13.3 ± 2.8 mmHg to 14.3 ± 2.1 mmHg (p < 0.01). No correlation was found between CAS score and macular BFI in all the analyzed levels. Conclusions Pulse therapy treatment can change macular BFI. In particular, two months alter pulse therapy, all the patients show an increase in macular vascular blood flow in each angiographic level. According to our results, angio-OCT analysis of the macular BFI may be a useful tool in the follow-up of TAO patients after pulse therapy. Purpose To evaluate changes in peripapillary vascular blood flow indices (PVBFI) in patients with thyroid-associated ophthalmopathy (TAO) using OCT angiography (OCTA) technology. Methods Patients with TAO and control subjects matched for age and sex were included in the study. Eye examination, Clinical Activity Score (CAS) evaluation and OCTA scan analysis (Topcon ImageNet 6; DRI OCT Triton, Topcon Corporation) were performed. In particular, PVBFI of the superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina (OR) and choriocapillaris (CC) layers were obtained by OCTA and extracted from 8-bit greyscale OCT images using the ImageJ software package. Results Twenty-six patients with TAO (19 females, mean age 54.7 ± 5.2 and 7 males, mean age 51.4 ± 16.3) were compared with 26 healthy subjects (15 females, mean age 48.2 ± 14.1 and 11 males, mean age 53.1 ± 15.2). Both DCP-PVBF and CC-PVBFI were significantly reduced in TAO patients compared to control eyes (28.6 ± 2.1 vs. 29.7 ± 0.93, p = 0.002; 46.5 ± 1.72 vs. 47.2 ± 1.2, p = 0.019 respectively); on the other hand, no statistically significant differences were found in SCP-PVBFI and OR-PVBFI in TAO patients compared to healthy subjects (p > 0.05). Also, CC-PVBFI was associated with elevated values of CAS (p = 0.018) and ROC curve showed that patients with elevated CC-PVBFI were correlated with active TAO (CAS > 3) (p = 0.012). Conclusions TAO disease may be associated with changes in DCP-PVBFI and CC-PVBFI; also, CC-PVBFI seems to correlate with disease activity. | |
| Handle: | http://hdl.handle.net/11567/1075633 | |
| Appare nelle tipologie: | Tesi di dottorato |
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| phdunige_3006115.pdf | Articolo | Tesi di dottorato | Open Access Visualizza/Apri |
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