Marselli et al. find that human β cell dysfunction induced by metabolic stresses is persistent or transient. RNA sequencing and eQTL analysis identify key pathways underlying failure and recovery. Type 2 diabetes β cells have several functional and molecular alterations and share specific transcriptomic traits of β cells with irreversible or rescuable damage.

Persistent or Transient Human β Cell Dysfunction Induced by Metabolic Stress: Specific Signatures and Shared Gene Expression with Type 2 Diabetes

Bugliani M.;De Luca C.;Bosi E.;
2020-01-01

Abstract

Marselli et al. find that human β cell dysfunction induced by metabolic stresses is persistent or transient. RNA sequencing and eQTL analysis identify key pathways underlying failure and recovery. Type 2 diabetes β cells have several functional and molecular alterations and share specific transcriptomic traits of β cells with irreversible or rescuable damage.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/1072802
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