Photosensitizing molecules have been at the basis of photodynamic therapy (PDT) since its early development in the 1950s. The therapy is a selective treatment method based on the administration of a photosensitizer to diseased cells: when irradiated with visible light of suitable wavelength, the photoactivated molecule starts a cascade of molecular transitions leading to cytotoxic effects in the targeted cells. The achievement of effective bio-compounds with photosensitizing capabilities and increased selectivity towards specific tumors is at the heart of the current research in the field. The aim of the herein project is to create an all-in-one multifunctional bio-molecule to be used in PDT treatments for melanoma cancer cells and holding targeting, imaging and photosensitizing potential.
A novel targeting approach for melanoma cancer treatment based on photodynamic therapy
Diaspro A.;
2021-01-01
Abstract
Photosensitizing molecules have been at the basis of photodynamic therapy (PDT) since its early development in the 1950s. The therapy is a selective treatment method based on the administration of a photosensitizer to diseased cells: when irradiated with visible light of suitable wavelength, the photoactivated molecule starts a cascade of molecular transitions leading to cytotoxic effects in the targeted cells. The achievement of effective bio-compounds with photosensitizing capabilities and increased selectivity towards specific tumors is at the heart of the current research in the field. The aim of the herein project is to create an all-in-one multifunctional bio-molecule to be used in PDT treatments for melanoma cancer cells and holding targeting, imaging and photosensitizing potential.
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