In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
Characterization of T lymphocytes in severe COVID-19 patients
Fenoglio D.;Dentone C.;Parodi A.;Di Biagio A.;Bozzano F.;Vena A.;Fabbi M.;Ferrera F.;Altosole T.;Bruzzone B.;Giacomini M.;Pelosi P.;De Maria A.;Bassetti M.;De Palma R.;Filaci G.
2021-01-01
Abstract
In this observational study, 13 patients with severe COVID-19 and 10 healthy controls were enrolled. The data concerning the analysis of circulating T cells show that, in severe COVID-19 patients, the expansion of these cell compartments is prone to induce antibody response, inflammation (CCR4+ and CCR6+ TFH) and regulation (CD8+ Treg). This pathogenic mechanism could lead us to envision a possible new form of biological target therapy.
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