Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors.
SIRT6 enhances oxidative phosphorylation in breast cancer and promotes mammary tumorigenesis in mice
Becherini, Pamela;Caffa, Irene;Piacente, Francesco;Damonte, Patrizia;Vellone, Valerio G;Passalacqua, Mario;Benzi, Andrea;Bonfiglio, Tommaso;Reverberi, Daniele;Khalifa, Amr;Ghanem, Moustafa;Tagliafico, Luca;Sucameli, Marzia;Persia, Angelica;Monacelli, Fiammetta;Cea, Michele;Bruzzone, Santina;Ravera, Silvia;Nencioni, Alessio
2021-01-01
Abstract
Sirtuin 6 (SIRT6) is a NAD+-dependent deacetylase with key roles in cell metabolism. High SIRT6 expression is associated with adverse prognosis in breast cancer (BC) patients. However, the mechanisms through which SIRT6 exerts its pro-oncogenic effects in BC remain unclear. Here, we sought to define the role of SIRT6 in BC cell metabolism and in mouse polyoma middle T antigen (PyMT)-driven mammary tumors.
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