A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small library of new molecules. Thanks to the presence of different functional groups, further cyclizations were performed providing bicyclic polyoxygenated heterocycles.

Synthesis of polyoxygenated heterocycles by diastereoselective functionalization of a bio-based chiral aldehyde exploiting the Passerini reaction

Banfi L.;Basso A.;Lambruschini C.;Moni L.;Riva R.
2020-01-01

Abstract

A chiral bio-based building block, prepared by the lipase-mediated desymmetrization of an erythritol derivative, was further functionalized and then submitted to stereoselective Passerini reactions, allowing the synthesis of a small library of new molecules. Thanks to the presence of different functional groups, further cyclizations were performed providing bicyclic polyoxygenated heterocycles.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11567/1035121
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