Nasal septum warthin’s tumor: A unique case report and review of the literature

Warthin’s tumor (WT) is the second most common benign salivary gland neoplasm following pleomorphic adenoma, accounting for approximately 5 to 15% of all salivary gland tumors. Extraparotid localizations of WT are only rarely described in ectopic salivary tissues. Salivary tumor findings are generally uncommon in the nasal cavity and usually correspond to malignant forms. Herein, we present the only case of nasal WT reported in the literature to our knowledge. A 56-year-old woman with a mild and intermittent right epistaxis lasting 1 year came to our attention reporting/ referring slowly growing mass in the right nasal vestibule from 6 months. Personal history showed 40 years of smoking habit. Management and Outcome: Endoscopic evaluation, T1-and T2-weighted magnetic resonance imaging sequences, and subsequent surgical removal with diode laser under general anesthesia were performed. The final histopathological diagnosis was margin-free nasal localization of WT. A PubMed research was performed with the following terms: [(adenolymphoma OR lymphomatous cystadenoma OR cystadenolymphoma OR papillary cystadenoma lymphomatosum OR Warthin) AND (nasal OR sinonasal OR nasal septum)], as long as a cross-linked references research from the articles found. No eligible articles were identified. The existence of extraparotid WT (EPWT) is believed to be a consequence of late encapsulation of the parotid gland during embryologic development with the intermingling of salivary and lymphoid tissues. Other authors have suggested that the lymphocytic component is the result of an immunological reaction to epithelial component proliferation. Nasal tumors are rare and extremely variable. Among salivary neoplasms in the nasal and paranasal sinuses district, pleomorphic adenoma cases were reported, but no nasal WT can be found described in the literature. Despite the unicity of this finding, sharing the diagnostic and therapeutic details of this case was considered to be potentially useful.