Anti-ApoA-1 IgGs predict resistance to waist circumference reduction after Mediterranean diet

The prevalence of obesity has doubled in the last half-century and continues to rise globally. However, a clear definition of this pathological condition, based on standardized clinically relevant variables, is still missing. Even the body mass index (BMI), which has been used for decades, has never emerged over traditional risk factors. Rather, the fall of BMI has contributed to reveal the heterogeneity of obesity 1 . Indeed, patients with similar BMI values - and body weight also - display different metabolic profiles and consequent cardiovascular (CV) risk. Body fat distribution and dysfunction (also referred to as "adiposopathy") has then become the new paradigm in obesity heterogeneity .