In patients with hepatitis C virus (HCV) and compensated advanced chronic liver disease (cACLD) there is evidence that sustained virological response (SVR) to direct-acting antivirals (DAA) may ameliorate portal hypertension, although both the course of oesophageal varices and the performance of their non-invasive predictors following DAA-induced SVR are less defined. In this study, our aim was to assess the variation in oesophageal varices status in HCV patients with cACLD who obtained an SVR to DAAs, and to evaluate the diagnostic performance of non-invasive predictors of varices after HCV cure.
Course of oesophageal varices and performance of non-invasive predictors following Hepatitis C Virus clearance in compensated advanced chronic liver disease
Giannini, Edoardo G;De Maria, Costanza;Crespi, Mattia;Demarzo, Maria Giulia;Fazio, Valentina;Torre, Francesco;Bodini, Giorgia;Marabotto, Elisa;Furnari, Manuele
2020-01-01
Abstract
In patients with hepatitis C virus (HCV) and compensated advanced chronic liver disease (cACLD) there is evidence that sustained virological response (SVR) to direct-acting antivirals (DAA) may ameliorate portal hypertension, although both the course of oesophageal varices and the performance of their non-invasive predictors following DAA-induced SVR are less defined. In this study, our aim was to assess the variation in oesophageal varices status in HCV patients with cACLD who obtained an SVR to DAAs, and to evaluate the diagnostic performance of non-invasive predictors of varices after HCV cure.
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