IRIS
DE TULLIO, ROBERTA
 Distribuzione geografica
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Continente #
EU - Europa 7.197
Totale 7.197
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Nazione #
IT - Italia 7.197
Totale 7.197
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Città #
Genova 5.512
Genoa 666
Rapallo 588
Vado Ligure 426
Bordighera 5
Totale 7.197
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Nome #
Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients 166
Role of the calpain-calpastatin system in the density-dependent growth arrest 156
Calpain digestion and HSP90-based chaperone protection modulate the level of plasma membrane F508del-CFTR. 156
Evidence for alteration of calpain/calpastatin system in PBMC of cystic fibrosis patients 155
Involvement of exon 6-mediated calpastatin intracellular movements in the modulation of calpain activation. 150
Activation of Ca2+-dependent proteolysis in skeletal muscle and heart in cancer cachexia. 149
Calpain inhibition promotes the rescue of F(508)del-CFTR in PBMC from cystic fibrosis patients. 148
Calpain3 is expressed in a proteolitically active form in papillomavirus-associated urothelial tumors of the urinary bladder in cattle. 144
Physiological Roles of Calpain 1 Associated to Multiprotein NMDA Receptor Complex. 141
Characterization of the calpastatin defect in erythrocytes from patients with essential hypertension. 140
Characterization of a new p94-like calpain form in human lymphocytes 134
Differential regulation of the calpain-calpastatin complex by the L-domain of calpastatin 134
Proteolytic degradation of nitric oxide synthase isoforms by calpain is modulated by the expression levels of HSP90. 131
Regulation of calpain activity in rat brain with altered Ca2+ homeostasis 130
A new human calpastatin skipped of the inhibitory region protects calpain-1 from inactivation and degradation 129
Changes in calpastatin localization and expression during calpain activation: a new mechanism for the regulation of intracellular Ca(2+)-dependent proteolysis. 128
Unexpected role of the L-domain of calpastatin during the autoproteolytic activation of human erythrocyte calpain. 128
Identification of a novel neutrophil membrane protein involved in modulation of oxidative burst. 127
The role of calpain in the selective increased phosphorylation of the anion-transport protein in red cell of hypertensive subjects. 127
Involvement of erythrocyte calpain in glycine- and carnitine-treated isovaleric acidemia. 124
The calpastatin defect in hypertension is possibly due to a specific degradation by calpain. 119
Interaction between Calpain-1 and HSP90: New Insights into the Regulation of Localization and Activity of the Protease. 119
Cell protection from Ca2+-overloading by bioactive molecules extracted from olive pomace 119
Multiple rat brain calpastatin forms are produced by distinct starting points and alternative splicing of the N-terminal exons. 119
Degradation of CFTR-generated protein clusters by calpain: A physiological or a pathological role? 118
“In vivo degradation of Nitric-Oxide Synthase isozymes by Calpain is regulated by HSP90” 116
Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover 114
Role of the regulatory domain of calpastatin in the autoproteolytic activation of calpain 112
Role of calpain-1 in the early phase of experimental ALS 112
Changes in intracellular localization of calpastatin during calpain activation 111
“Susceptibility of NOS isoforms to calpain digestion is modulated by the expression levels of HSP90” 110
Changes in intracellular calpastatin localization are mediated by reversible phosphorylation 104
Interference with Ca2+-Dependent Proteolysis Does Not Alter the Course of Muscle Wasting in Experimental Cancer Cachexia. 104
Age-dependent degradation of calpastatin in kidney of hypertensive rats 102
Different susceptibility of red cell membrane proteins to calpain degradation. 101
In vivo degradation of nitric oxide synthase (NOS) and heat shock protein 90 (HSP90) by calpain is modulated by the formation of a NOS-HSP90 heterocomplex 99
Is the Expression of [-G93A(+)] human SOD1 a model to study neurodegenerations? 99
Phosphorylation of rat brain calpastatins by protein kinase C. 96
"Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease?" 95
Calpain-mediated activation of NO synthase in human neuroblastoma SK-N-BE cells 92
Cytosolic levels of calpastatin are regulated by limited proteolysis 88
Modulation of rat brain calpastatin efficiency by post-translational modifications 87
Enhanced activation of the respiratory burst oxidase in neutrophils from hypertensive patients. 87
Differential degradation of calpastatin by mu- and m-calpain in Ca(2+)-enriched human neuroblastoma LAN-5 cells. 87
Regulation of the calpain-calpastatin system in rat brain during alteration of Ca2+ homeostasis 86
Site-directed activation of calpain is promoted by a membrane-associated natural activator protein 86
"Cytosolic levels of calpastatin are regulated by limited proteolysis" 85
Properties of calpastatin forms in rat brain 84
Adaptive modifications in the calpain/calpastatin system in brain cells after persistent alteration in Ca2+ homeostasis 84
A Bioactive Olive Pomace Extract Prevents the Death of Murine Cortical Neurons Triggered by NMDAR Over-Activation 84
“Involvement of the Calpain/Calpastatin System in Familial Amyotrophic Lateral Sclerosis” 83
“How is alteration in Ca2+ homeostasis controlled in brain? A role for calpastatin” 83
Rat brain contains multiple mRNAs for calpastatin 80
Production and purification of recombinant calpastatin 77
“Regulation of calpain activity in brain following altered Ca2+ homeostasis” 76
Isolation of endogenous calpastatin 73
Bioactive molecules isolated from olive pomace extract protect cells from calcium mediated damages 72
"Intracellular calpastatin proteolysis: a salvage mechanism or a prelude to cell damage?" 70
Modulation of calpastatin specificity in rat tissues by reversible phosphorylation and dephosphorylation. 69
Specific role of calpain-1 associated to N-methy l-D-aspartate receptor in lipid rafts microdomains 66
Association of calpastatin with inactive calpain: a novel mechanism to control the activation of the protease? 66
Differential regulation of mu- and m-calpain in rat hearts perfused with Ca2+ and cAMP. 65
Interaction between catalitically inactive calpain and calpastatin: evidence for its occurrence in stimulated cells 64
Specific degradation of troponin T and I by mu-calpain and its modulation by substrate phosphorylation. 63
“Entry in the quiescent G0 cell state requires enhanced calpain activation” 63
Immunoblotting for calpastatin expression 62
Respiratory burst in activated neutrophis is directly correlated to the intracellular level of protein kinase C 61
Functional role of HSP90 complexes with endothelial nitric-oxide synthase (eNOS) and calpain on nitric oxide generation in endothelial cells 61
The calpain-calpastatin system in human central nervous system tumours: new insight on its prognostic value 58
Identification of potential leukocyte biomarkers related to drug recovery of cftr: Clinical applications in cystic fibrosis 44
Temperature-Dependent Olive Pomace Extraction for Obtaining Bioactive Compounds Preventing the Death of Murine Cortical Neurons 42
GenBank: MK585065.1: Homo sapiens calpastatin (CAST) mRNA, complete cds 28
GenBank: MF577037.1: Homo sapiens clone hcast 3-25 calpastatin (CAST) mRNA, partial cds 25
Modulation of Plasmatic Matrix Metalloprotease 9: A Promising New Tool for Understanding the Variable Clinical Responses of Patients with Cystic Fibrosis to Cystic Fibrosis Transmembrane Conductance Regulator Modulators 19
Expression of calpastatin hcast 3-25 and activity of the calpain/calpastatin system in human glioblastoma stem cells: possible involvement of hcast 3-25 in cell differentiation 15
Possible etiological association of ovine papillomaviruses with bladder tumors in cattle 14
Totale 7.315
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Categoria #
all - tutte 21.055
article - articoli 15.860
book - libri 0
conference - conferenze 4.304
curatela - curatele 0
other - altro 288
patent - brevetti 0
selected - selezionate 0
volume - volumi 603
Totale 42.110
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/20201.647 0 0 0 0 185 218 289 137 169 322 248 79
2020/2021486 27 48 35 46 25 36 26 52 36 68 36 51
2021/2022899 31 72 56 84 24 56 63 212 36 88 37 140
2022/2023711 60 41 8 90 98 116 1 52 126 6 100 13
2023/2024487 23 53 8 48 54 116 20 16 29 13 29 78
2024/2025495 131 130 37 108 89 0 0 0 0 0 0 0
Totale 7.315