TORTOLINA, LORENZO
TORTOLINA, LORENZO
100007 - Dipartimento di Medicina interna e specialità mediche
A multi-scale approach to colorectal cancer: from a biochemical- interaction signaling-network level, to multi-cellular dynamics of malignant transformation. Interplay with mutations and onco-protein inhibitor drugs.
2012-01-01 Tortolina, Lorenzo; Castagnino, N; De Ambrosi, C; Moran, Eva; Patrone, Franco; Ballestrero, Alberto; Parodi, Silvio
Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies.
2015-01-01 Tortolina, Lorenzo; Duffy, Dj; Maffei, Massimo; Castagnino, Nicoletta; Carmody, Am; Kolch, W; Kholodenko, Bn; DE AMBROSI, Cristina; Barla, A; Biganzoli, Em; Nencioni, Alessio; Patrone, Franco; Ballestrero, Alberto; Zoppoli, Gabriele; Verri, Alessandro; Parodi, Silvio
Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells
2021-01-01 Sommariva, S.; Caviglia, G.; Ravera, S.; Frassoni, F.; Benvenuto, F.; Tortolina, L.; Castagnino, N.; Parodi, S.; Piana, M.
Dynamic Simulations of Pathway Cross-talks Relevant in Colorectal Cancer: A Quantitative Parameter Sensitivity Analysis
2011-01-01 DE AMBROSI, Cristina; Barla, Annalisa; Tortolina, Lorenzo; Castagnino, Nicoletta; R., Pesenti; Verri, Alessandro; Ballestrero, Alberto; Patrone, Franco; Parodi, Silvio
Dynamic simulations of pathways downstream of ERBB-family, including mutations and treatments. Concordance with experimental results.
2010-01-01 Castagnino, Nicoletta; Tortolina, Lorenzo; Balbi, Alessandro; Pesenti, R; Montagna, R; Ballestrero, Alberto; Soncini, Debora; Moran, E; Nencioni, Alessio; Parodi, Silvio
Dynamic simulations of pathways downstream of TGF-beta , Wnt and EGF-family growth factors, in colorectal cancer, including mutations and treatments with onco-protein inhibitors
2012-01-01 Tortolina, Lorenzo; Castagnino, Nicoletta; Ambrosi, C. De; Barla, Annalisa; Verri, Alessandro; Zoppoli, G.; Bagnasco, Luca; Piras, Daniela; Patrone, Franco; Ballestrero, Alberto
Dynamic simulations of pathways downstream of TGF-β , Wnt and EGF-family grow- th factors, in colorectal cancer, including mutations and treatments with onco-protein inhibitors
2012-01-01 Tortolina, Lorenzo; Castagnino, Nicoletta; DE AMBROSI, Cristina; Barla, Annalisa; Verri, Alessandro; Zoppoli, Gabriele; Bagnasco, Luca; D., Piras; Patrone, Franco; Ballestrero, Alberto; Parodi, Silvio
Effects of Parameter Space Exploration within Dynamic Simulations of Pathways Downstream of Erbb-family on Breast Cancer
2011-01-01 DE AMBROSI, Cristina; Tortolina, Lorenzo; Castagnino, Nicoletta; R., Pesenti; Barla, Annalisa; Verri, Alessandro; Ballestrero, Alberto; Parodi, Silvio
Inhibition of a protein-protein interaction between INI1 and c-Myc by small peptidomimetic molecules inspired by Helix-1 of c-Myc: Identification of a new target of potential antineoplastic interest
2007-01-01 Bagnasco, Luca; Tortolina, Lorenzo; Biasotti, B.; Castagnino, Nicoletta; Ponassi, Raffaella; Tomati, V.; Nieddu, Erika; Stier, G.; Malacarne, D.; Parodi, Silvio
Parameter Space Exploration within Dynamic Simulations of a Signaling Network Downstream of TGF-beta, WNT and EGF-family growth factors, with reference to colorectal cancer
2011-01-01 Barla, Annalisa; DE AMBROSI, Cristina; Tortolina, Lorenzo; Castagnino, Nicoletta; Pesenti, R.; Verri, Alessandro; Ballestrero, Alberto; Patrone, F.; Parodi, S.
Parameter Space Exploration within Dynamic Simulations of Signaling Networks
2013-01-01 C., De Ambrosi; Barla, Annalisa; Tortolina, Lorenzo; Castagnino, Nicoletta; R., Pesenti; Verri, Alessandro; Ballestrero, Alberto; Patrone, Franco; Parodi, Silvio
Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial
2016-01-01 Castagnino, Nicoletta; Maffei, Massimo; Tortolina, Lorenzo; Zoppoli, Gabriele; Piras, Daniela; Nencioni, Alessio; Moran, Eva; Ballestrero, Alberto; Patrone, Franco; Parodi, Silvio
Systems medicine in oncology: Signaling network modeling and new-generation decision-support systems
2016-01-01 Parodi, Silvio; Riccardi, Giuseppe; Castagnino, Nicoletta; Tortolina, Lorenzo; Maffei, Massimo; Zoppoli, Gabriele; Nencioni, Alessio; Ballestrero, Alberto; Patrone, Franco
| Titolo | Data di pubblicazione | Autore(i) | File |
|---|---|---|---|
| A multi-scale approach to colorectal cancer: from a biochemical- interaction signaling-network level, to multi-cellular dynamics of malignant transformation. Interplay with mutations and onco-protein inhibitor drugs. | 1-gen-2012 | Tortolina, Lorenzo; Castagnino, N; De Ambrosi, C; Moran, Eva; Patrone, Franco; Ballestrero, Alberto; Parodi, Silvio | |
| Advances in dynamic modeling of colorectal cancer signaling-network regions, a path toward targeted therapies. | 1-gen-2015 | Tortolina, Lorenzo; Duffy, Dj; Maffei, Massimo; Castagnino, Nicoletta; Carmody, Am; Kolch, W; Kholodenko, Bn; DE AMBROSI, Cristina; Barla, A; Biganzoli, Em; Nencioni, Alessio; Patrone, Franco; Ballestrero, Alberto; Zoppoli, Gabriele; Verri, Alessandro; Parodi, Silvio | |
| Computational quantification of global effects induced by mutations and drugs in signaling networks of colorectal cancer cells | 1-gen-2021 | Sommariva, S.; Caviglia, G.; Ravera, S.; Frassoni, F.; Benvenuto, F.; Tortolina, L.; Castagnino, N.; Parodi, S.; Piana, M. | |
| Dynamic Simulations of Pathway Cross-talks Relevant in Colorectal Cancer: A Quantitative Parameter Sensitivity Analysis | 1-gen-2011 | DE AMBROSI, Cristina; Barla, Annalisa; Tortolina, Lorenzo; Castagnino, Nicoletta; R., Pesenti; Verri, Alessandro; Ballestrero, Alberto; Patrone, Franco; Parodi, Silvio | |
| Dynamic simulations of pathways downstream of ERBB-family, including mutations and treatments. Concordance with experimental results. | 1-gen-2010 | Castagnino, Nicoletta; Tortolina, Lorenzo; Balbi, Alessandro; Pesenti, R; Montagna, R; Ballestrero, Alberto; Soncini, Debora; Moran, E; Nencioni, Alessio; Parodi, Silvio | |
| Dynamic simulations of pathways downstream of TGF-beta , Wnt and EGF-family growth factors, in colorectal cancer, including mutations and treatments with onco-protein inhibitors | 1-gen-2012 | Tortolina, Lorenzo; Castagnino, Nicoletta; Ambrosi, C. De; Barla, Annalisa; Verri, Alessandro; Zoppoli, G.; Bagnasco, Luca; Piras, Daniela; Patrone, Franco; Ballestrero, Alberto | |
| Dynamic simulations of pathways downstream of TGF-β , Wnt and EGF-family grow- th factors, in colorectal cancer, including mutations and treatments with onco-protein inhibitors | 1-gen-2012 | Tortolina, Lorenzo; Castagnino, Nicoletta; DE AMBROSI, Cristina; Barla, Annalisa; Verri, Alessandro; Zoppoli, Gabriele; Bagnasco, Luca; D., Piras; Patrone, Franco; Ballestrero, Alberto; Parodi, Silvio | |
| Effects of Parameter Space Exploration within Dynamic Simulations of Pathways Downstream of Erbb-family on Breast Cancer | 1-gen-2011 | DE AMBROSI, Cristina; Tortolina, Lorenzo; Castagnino, Nicoletta; R., Pesenti; Barla, Annalisa; Verri, Alessandro; Ballestrero, Alberto; Parodi, Silvio | |
| Inhibition of a protein-protein interaction between INI1 and c-Myc by small peptidomimetic molecules inspired by Helix-1 of c-Myc: Identification of a new target of potential antineoplastic interest | 1-gen-2007 | Bagnasco, Luca; Tortolina, Lorenzo; Biasotti, B.; Castagnino, Nicoletta; Ponassi, Raffaella; Tomati, V.; Nieddu, Erika; Stier, G.; Malacarne, D.; Parodi, Silvio | |
| Parameter Space Exploration within Dynamic Simulations of a Signaling Network Downstream of TGF-beta, WNT and EGF-family growth factors, with reference to colorectal cancer | 1-gen-2011 | Barla, Annalisa; DE AMBROSI, Cristina; Tortolina, Lorenzo; Castagnino, Nicoletta; Pesenti, R.; Verri, Alessandro; Ballestrero, Alberto; Patrone, F.; Parodi, S. | |
| Parameter Space Exploration within Dynamic Simulations of Signaling Networks | 1-gen-2013 | C., De Ambrosi; Barla, Annalisa; Tortolina, Lorenzo; Castagnino, Nicoletta; R., Pesenti; Verri, Alessandro; Ballestrero, Alberto; Patrone, Franco; Parodi, Silvio | |
| Systems medicine in colorectal cancer: from a mathematical model toward a new type of clinical trial | 1-gen-2016 | Castagnino, Nicoletta; Maffei, Massimo; Tortolina, Lorenzo; Zoppoli, Gabriele; Piras, Daniela; Nencioni, Alessio; Moran, Eva; Ballestrero, Alberto; Patrone, Franco; Parodi, Silvio | |
| Systems medicine in oncology: Signaling network modeling and new-generation decision-support systems | 1-gen-2016 | Parodi, Silvio; Riccardi, Giuseppe; Castagnino, Nicoletta; Tortolina, Lorenzo; Maffei, Massimo; Zoppoli, Gabriele; Nencioni, Alessio; Ballestrero, Alberto; Patrone, Franco |