The genus Premna (Lamiaceae) contains 200 species mainly distributed throughout tropical and subtropical Asia, Africa, Australia, and the Pacific Islands. 1 46 species are recognized in the Flora of China and 14 species in the Flora Malesiana area.1 Most species in the genus are small trees or shrubs and rarely found as lianas and pyroherbs 1. Common metabolites of the genus are diterpenoids, triterpenoids, iridoid glycosides, flavonoids lignans and xanthones.1,2 The diversity of species of Premna throughout the habitat region results in various traditional uses by the local people,1 to treat malaria, stomach and hepatic disorders, headache, cough, malaria and tuberculosis, infectious-related diseases, skin diseases, asthma, rheumatism, neuralgia, diarrhea and stomach disorder, hyperglycaemic, and obesity.1,2 Extracts and isolated compounds from leaves, root bark and stem bark have shown antioxidant, antibacterial, anti-inflammatory, cytotoxic, antifeedant and heapatoprotective activity.1,2 The essential oil obtained from Premna species displayed antibacterial properties.2 P. resinosa, a shrub or small bushy tree, with whitish stems and coriaceous leaves with a pleasant smell, is used in Indian traditional medicine, as laxative agent and to treat bronchitis. The extracts of P. resinosa and their flavonoid constituents showed cytotoxic, anti-tubercular, and antimicrobial activities.2,3 The dichloromethane extract of the surface mixture, obtained from the fresh aerial parts of P. resinosa, was separated by different chromatographic techniques such as Silica gel, MPLC, and HPLC, and afforded five new and one known labdane diterpene whose structures were elucidated by NMR and MS Spectroscopy. The antiproliferative activity of the isolates was investigated on Jurkat and HeLa cell lines. The most active diterpene (1) at 48 h showed activity in both cell lines (IC50 of 13 ± 0.7 µM and 16 ± 0.9 µM, respectively).
File in questo prodotto:
Non ci sono file associati a questo prodotto.