The phosphorylation of Tau protein is finely regulated by a balance between phosphorylation and dephosphorylation processes carried out by kinases and phosphatases. It has been suggested that the disruption of this equilibrium and the consequent abnormal Tau phosphorylation contribute to its aggregation. The understanding of this important mechanism is of high interest because of the implication of Tau aggregates in the development of Alzheimer’s Disease (AD). In the last few years, among the possible strategies which could be used to revert Tau phosphorylation, the inhibition of certain tyrosine kinases has been suggested as a promising alternative to the common therapies. In this chapter we will give at first an overview on the tau protein kinases, their roles in cells, regulation and their importance in AD. Then, a more detailed description of the role of Fyn, a member of the Src family kinases, in the physiological development of CNS and the pathological progress of AD, will be given. It will be discussed how the inhibition of Fyn could be used as a new strategy in the fight against AD.
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|Titolo:||Inhibitors of tau-phosphorylating kinases|
|Data di pubblicazione:||2017|
|Appare nelle tipologie:||02.01 - Contributo in volume (Capitolo o saggio)|