As a part of our phytochemical research on species of the genus Salvia cultivated in Italian “Riviera dei Fiori” (Liguria) we began a study of Salvia corrugata Vahl. The surface exudate, obtained by immersion of the fresh aerial parts in CH2Cl2 showed a significant antifungal activity against Colletotrichum gloeosporioides, Fusarium oxysporum f.sp. basilici, Botrytis cinerea and Rhizoctonia solani. Until now by repeated column chromatography on Sephadex LH-20 we have isolated one triterpenoid (1) and two diterpenoids (2-3). Compound 1 was identified as ursolic acid by direct comparison with authentic sample previously isolated from natural source; compounds 2 and 3 were identified as demethylfruticulin A and fruticulin A from the 1H- and 13C-NMR spectra and on the basis of 1H-1H-COSY, TOCSY, ROESY, HSQC and HMBC correlations.
Antifungal activity of S. corrugata Vahl.
BISIO, ANGELA;ROMUSSI, GIOVANNI;
2006-01-01
Abstract
As a part of our phytochemical research on species of the genus Salvia cultivated in Italian “Riviera dei Fiori” (Liguria) we began a study of Salvia corrugata Vahl. The surface exudate, obtained by immersion of the fresh aerial parts in CH2Cl2 showed a significant antifungal activity against Colletotrichum gloeosporioides, Fusarium oxysporum f.sp. basilici, Botrytis cinerea and Rhizoctonia solani. Until now by repeated column chromatography on Sephadex LH-20 we have isolated one triterpenoid (1) and two diterpenoids (2-3). Compound 1 was identified as ursolic acid by direct comparison with authentic sample previously isolated from natural source; compounds 2 and 3 were identified as demethylfruticulin A and fruticulin A from the 1H- and 13C-NMR spectra and on the basis of 1H-1H-COSY, TOCSY, ROESY, HSQC and HMBC correlations.
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