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EnglishNumerous clinical trials demonstrated that the optimal log-term treatment of pelvic pain caused by endometriosis may involve the use of GnRH ana- logues (GnRH-a) to suppress ovarian estrogen production combined with add- back low doses of estrogen plus progestin or progestin only. Estrogen, as a solitary add back, is less effective and thus is not indicated. Tibolone can be used as add back therapy to prevent hypoestrogenic symptoms. Recently, the post-operative administration of GnRH-a and anastrozole have been suggested to increase the pain-free interval and decrease symptom recurrence rates in patients following surgery for severe endometriosis.
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| Titolo: | Double-Drug Regimen Using GnRH Analogues |
| Autori: | |
| Data di pubblicazione: | 2006 |
| Abstract: | Numerous clinical trials demonstrated that the optimal log-term treatment of pelvic pain caused by endometriosis may involve the use of GnRH ana- logues (GnRH-a) to suppress ovarian estrogen production combined with add- back low doses of estrogen plus progestin or progestin only. Estrogen, as a solitary add back, is less effective and thus is not indicated. Tibolone can be used as add back therapy to prevent hypoestrogenic symptoms. Recently, the post-operative administration of GnRH-a and anastrozole have been suggested to increase the pain-free interval and decrease symptom recurrence rates in patients following surgery for severe endometriosis. |
| Handle: | http://hdl.handle.net/11567/393068 |
| ISBN: | 9788875872397 |
| Appare nelle tipologie: | 04.01 - Contributo in atti di convegno |
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